These cells form a continuous covering for sinusides. They are different of the endoteliais cells of other places because it does not have a regular basal blade. The cells of Kupffer are more numerous close to the spaces carry. They derive from the ssea marrow and they belong to the fagoctico mononuclear system, corresponding about 80 90% of the fixed macrophages in the human body, the cells of Kupffer are highly inserted mobile macrophages in the endotelial covering of sinuside, over all in the periportal area. The cells of Kupffer are coram with peroxidase. They possess corpsculos microvilosidades, intracitoplasmticas vesicles coated and dense that understand the lisossmico apparatus. The hepticas covered with star cells place in the space between the hepatcitos and the endoteliais cells. The space contains tecidual liquid that flows for the lymphatic ones in the space-door.

When venoso heptico has blockage of refluxo, the production of lymph in the space increases and has ascite formation. (JUNQUEIRA; SHEEP, 2004). 1,5 FUNCTIONS OF in agreement LIVER affirm Berne and Levy, (2007) ' ' the liver it plays many vital functions. It is essential in the regulation of the metabolism, the synthesis of proteins and of other molecules, in the storage of vitamins and iron, in the hormonal degradation and the inativao and excreo of medicines (drugs) and toxinas' '. This voluminous gland exerts innumerable functions, at the same time endcrinas and excrinas, acting in the metabolism of the carboidratos, the lipdios and proteins, being the liver and the esqueltico muscle the main places of storage of the glycogen in the body. The liver has the function To convert ammonia. From the protein the amino acids for gliconeognese are used, resulting in the ammonia formation as a by-product. Metabolically the liver will go to convert this ammonia into urea. The ammonia produced for bacteria in the intestine is removed of the blood carries for the urea synthesis.

Authority also is called being able legitimate; for specialization is obtained by means of knowledge, abilities or experience. (FOUCAULT; 1979, P. 29) 1,3 the ORIGIN OF the POWER IN the NURSING the nursing is a science that comes conquering throughout history, autonomy and power, this conquest was initiated by Florence Nightingale, as it tells to Vieira (1991) the origin of the Modern Nursing if it gave decurrent the Florence Nightingale, in the whole world, getting bigger reach from its voluntary participation in ‘ ‘ War of the Crimia’ ‘. However, Florence nailed the superiority of knowing doctor in detriment of knowing of nursing. Since Florence he disciplines it to Nightingale, the obedience and the subservincia in the nursing, are considered as indissocivel part of the daily exercise, not only in what they concern the assistenciais actions, as well as the relations between nurse and the doctor, the team of nursing and the hospital administration. (Foucault; 1982 apud PADILHA; , 1997, P. 02). Before the institutionalization of the profession, the power was exerted for religious, Until the middles of century XVIII, the religious ones withheld the institucional power.

However, from the moment where the hospital is conceived as an instrument of cure and distribution of the space becomes a therapeutical instrument, the medical one starts to be main the responsible one for the hospital organization, and the religious community is banished so that the space can medically be organized. (Foucault, 1982 apud PADILHA, 1997, P. 02). With the medicalizao of the hospitals, knowing was established doctor and to know of the nursing, that in accordance with Vieira (1991), with the appearance of the category of ‘ ‘ enfermeiro’ ‘ the hospital well ‘ ‘ disciplinado’ ‘ , the adequate place of ‘ consisted; ‘ it disciplines mdica’ ‘.

MEDICINE RATIONAL USE Laura Viviane G. of Oliveira Rodrigues SUMMARY In view of the increase of the self-medication, that is, on account proper medicine use, without medical lapsing or orientation of professional of the health for the Brazilian population, brings bigger challenges each time to the services and the professionals of health. It appears, therefore a great challenge not only the pharmaceutical classroom, but also the public health of the country that makes use of strategies and orientaes to promote the use rational of medicines. Word-key: Medicines. Rational use. ABSTRACT Given the increase in self-medication, or drug uses on to their own without prescription or guidance from the health professional population, brings increasing challenges you the services and health professionals. Appears therefore great challenge not only you pharmacists but also the public health of the country that offers strategies and guidelines you promote the rational uses of medicines.

Word-key: Medication. Rational uses. INTRODUCTION According to decree Law n176/2006 medicine is all the substance substance or association presented as possessing curativas or preventive properties of illnesses in human beings or its symptoms or that it can be used or be managed in the human being with sight to establish a medical diagnosis or, exerting a farmacolgica, imunolgica or metabolic action, to restore, to correct or to modify functions fisiolgicas' '. However the Brazilian population has if used of the practical one of the self-medication, that is, on account proper medicine use, without medical lapsing or orientation of professional of the health giving excuses that already know the problem the same and is of easy resolution and immediately decided without needing doctor, also due the difficulty in having access to the health services, Stimulated for the advertising, the people buy in the pharmacy vitamins that could get in natural fruits; association between ' ' sade' ' ' ' medicamento' ' , they believe that the more medicines to use more health will have.

The main physical characteristic aspects are: described brachycephaly with achatamento of the occipital region, round face with presence of palpebrais cracks (for it are and top) and epicnicas folds; eyes presenting spots of Brushfield of the edge of the Iris and have around taken convergent estrabismo, nose small with the flattened tip, mouth and small teeth, language protusa, pparently great with presence of ridges, small ears with low implantation, the eyes, the nose and the mouth are next than the normal one. (GONZALEZ, 2002; PUESCHEL, 1993) cited for Dborah Maroja. ‘ ‘ The term ‘ ‘ sndrome’ ‘ it more comumente constitutes a combination of resultant symptoms of an only alteration or comumente in set, constituting a clinical figure distinta’ ‘. (BOTTOMLEY, Jennifer M, 2003). The Syndrome of Down (SD) if constitutes in a factor of genetic anomaly characterized by the presence of an additional chromosome 21, that is, it are of normalities of the human being, being thus also known as trissomia of the 21, on account of this syndrome the carrying individual possesss specific physical and mental characteristics, and some global ones thus facilitating the diagnosis of the syndrome. ‘ ‘ This syndrome is considered one of the most frequent anomalies of the autossmicos chromosomes and represents the oldest cause of retardation mental’ ‘.

(GONALVES, 2003) cited for Dborah Maroja. The evidentes mental characteristics, that is, more frequent vary since a delay of the neuropsicomotor development in the lesser children until a mental retardation in bigger children. Literature points that the picture of mental deficiency is serious, therefore is since 80% of the children have low QI, between 25 and 30. These alterations frequently gifts in these children can be disclosed functionally, thus being able to intervene with the capacity of the same ones to play of independent form, the activities and tasks of known the daily routine the AVDs.

The acceptance comes a time later, when it is perceived that all the efforts had been useless, alone remains to accept reality. He is one I serve as apprentice of serenity, rest and moment to use to advantage the last moments of life, next to wanted beings, reconciling with less the most wanted. Express Oscar this feeling when he says ‘ ‘ I tried to explain my parents who the life is a present stranger. At the beginning, we overestimate this gift: we imagine to have gained the life perpetual. Later we subestimamos, we find a nastiness excessively, short, until we would be capable to play it are it. At last in we give account to them that was not a gift, but yes a loan. Then we look merec-lo’ ‘. To understand that we are in the ticket world is very important, makes with that better let us accept our victories, failures, dreams and disillusions.

The life as Oscar says is ‘ ‘ one emprstimo’ ‘ , and each as he is only. The Hope is a present factor in all the moments. Although of not visible form, each I serve as apprentice is a form to express the hope. It is who motivates the fight for the life. Oscar shows the hope when he says that ‘ ‘ he does not have solution for the life seno viver’ ‘. the secret of this hope is: ‘ ‘ to each day it looks at the world as if it saw ‘ for the first time to it; ‘. It is important to say that these periods of training can happen of random form and they are not only lived deeply by the patients, the family, friends, next people, also live deeply, them. For the nursing professional, to understand these processes allows a more efficient boarding, becomes the convivncia with the patient and more pleasant family and prevents conflicts.

This care with the life does not have to be given only to the patients, the proper nurse, the team of nursing, doctors and other professionals of health need to understand the life, the life and the process of death, to value this ‘ ‘ emprstimo’ ‘ that he is granted to all. BIBLIOGRAPHICAL REFERENCES SCHIMITT, Eric-Emmanuel.

The gastric secretion mechanism and the factors related to the formation of the peptic ulcer are important aspects for the medicine development new that can act as antagonistic in these processes. The used medicines as citoprotetores tend to increase the resistance of the gastric mucosa and to diminish the harmful agents (CAVALINI, 2005). 3.3. Mechanisms of gastric protection Physiological, the aggressive and protective agents of the gastric mucosa are in balance. The concentration of H+ in the lumen of the stomach is raised, however, mechanisms exist that hinder its return for the gastric cells. Amongst the protective mechanisms it is to the stimulation of the mucous cells, for the Ach, for protective release of muco (MILK, 2004).

The electric resistance of the membrane of the epithelial cells, the high cellular junctions and the negative electric potential of the way hinder the passive ticket them ons H+ through the cellular membranes. The defense of the gastric mucosa is based on three main mechanisms: humorais (release of E2 Prostaglandin) and nitric oxide (IN), neural (sensorial neurons) and functionaries (secretion of muco, motilidade and microcirculation) (RODRIGUES, 2008). The mucous cells liberate muco protective, forming viscous, transparent, adherent and elastic a system (95% water and 5% glycoproteins). Muco recovers the fabric gastric, acting as a sweeper of free radicals, aid in cellular regeneration and the cicatrizao of ulcerativas injuries (RODRIGUES, 2008). The barrier muco-bicarbonate-fosfolipdios hinders the installation of microorganisms, making physical protection against foods and acts as a powerful lubricant (ROZZA, 2009).

In the interior of the cells of the mucosa, the oxidation-reduction system functions (redox), that it acts as a citoprotetor system. The free radicals are formed physiological and in inflammatory processes, then, the system redox if it becomes essential for the reduction of less reactive free radicals ons, increasing the cellular protection (MAYER, 2007).

The joined results show that for the most part of the users acometidos for the IRC taken care of in the sector of hemodilise of a hospital of the city of Cricima- SC they are of the masculine sex. In accordance with some authors, the IRC acomete patient with age enters the 40 60 years and has short while bigger incidence between men of what in mulheres3,6. In studies carried through for other authors, about 53,2% of the total sample they were patient of masculine sex e, in the casuistry of one another found study, that consisted of 50 patients, 56% were of masculine sex and 44% of the feminine one, results these similars to the gift estudo7,8. It was possible to observe, from this study, that the users had presented great prevalence of anemia, about 75%, being that the anemia of the normoctica type was most prevalent with 55% of the sample. The anemia in the chronic renal insufficiency is characteristically normocrmica, normoctica and with counting of red cells in the normal or diminished ssea marrow, had to its character hipoproliferativo5,9,10. The determinative factor of the present serious anemia in the chronic nefropatia is the deficiency of production of the eritropoetina for tubular epitlio 7,9. However, it has assumptions of that the urmicas toxins also inhibit the eritropoetina, and reduce the time of life of eritrcitos3,4.

Of this form, contributing for the understanding and the recognition of the essencialidade of sleep, sleeping well and being intent to the alterations of this process, that is basic to the life. Word-key: Paradoxical sleep REM or. Sleep NREM or of slow waves. System of Temporization. Quality of sleep. Riots of sleep.

ABSTRACTThis research went the assumption that most people of not understand the real value of sleep because of this, the aim of this paper is you present you the community in general the magnificent and complex process of sleep, their characteristics, information on to their quality and its disturbances. Thus, contributing you the understanding and recognition of the essential sleep, you sleep well and be aware of changes in that process, which is basic you life. Key-words: Paradoxical REM sleep or. NREM sleep or slow waves. System the Timer. Quality of sleep. Sleep disturbances. Sleep Has much time sleep is focus of great scientific inquiries, since she is one of the functions most fascinating of our human body.

Old studies affirmed that, at the time from the primitive man, it moved away them to sleep from its nocturnal predators and it served as physiological rest, therefore sleep always was important to the man, in divergent way at different moments of history. According to Louzada and Menna-Barreto (2007, P. 57), ‘ ‘ for return of the half of the last century was even given credit that sleep was a passive process, something similar to? disconnection? temporary of crebro’ ‘. It is certain that still it is a very ample field for inquiries, but many discoveries already had proven that it is indispensable to our development, since even though the animal irrationals need this process.